Catalog Number - 68122-15P-2

The 68122‑15P‑2 Cogent RP PFP™ UHPLC Column is designed for high‑resolution separation of halogenated, aromatic, and polar compounds, delivering enhanced selectivity where conventional C18 phases may not fully resolve analytes.

This stationary phase features a pentafluorophenyl (PFP) ligand bonded via a four‑carbon linker to high‑purity silica with full double end‑capping, providing multiple interaction mechanisms including π‑π interactions, dipole interactions, and hydrogen bonding. This enables greater selectivity control and improved separation of structurally similar compounds.

The phase is well suited for USP L43 methods and for advanced method development where alternative retention behavior is required.

150 mm Length – High Resolution for LC‑MS Workflows

The 150 mm length provides greater resolving power than shorter columns, making it ideal for difficult separations and complex sample analysis.

• Higher resolution than 50 mm and 100 mm columns

• Improved separation of closely related compounds

• Increased peak capacity for complex and trace-level samples

✅ Use when maximum resolution is required beyond 100 mm columns

Flow Rate & System Requirements (2.1 mm ID, 1.8 µm)

⚠️ Requires UHPLC system capability due to high backpressure

• Typical flow rate range: ~0.2–0.4 mL/min

• Optimal starting range: ~0.25–0.35 mL/min

• Requires precise, stable low‑flow pumping

• Compatible with low‑volume LC‑MS detectors

✅ Sample preparation requirement: filter samples using a 0.2 µm syringe filter prior to injection

Why Choose PFP for Selective Separations

Enhanced Retention for Halogenated Compounds

• Strong interaction with fluorinated and halogenated analytes

• Improved selectivity compared to C18

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Broad selectivity flexibility in method development

Maximum Resolution for Complex Samples

• Higher peak capacity for difficult separations

• Ideal for advanced LC‑MS method optimization

Cogent RP PFP™ Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry for polar analytes

High Efficiency (1.8 µm Particles)

• High plate counts and peak capacity

• Enables high‑resolution, fast separations

High Purity Silica

• Consistent performance and reproducibility

• Reliable method transfer and validation

Typical Applications

• Halogenated compound analysis

• Aromatic compound separations

• Pharmaceutical method development

• LC‑MS analytical workflows

• USP L43 method applications

Important Usage Notes

• ⚠️ Requires UHPLC system (high pressure capable)

• Designed for low‑flow LC‑MS workflows

• Higher backpressure than larger particle columns

• Use 0.2 µm filtration to maintain column performance